Taking on Chronic Hepatitis B
A New Approach to Treating Chronic Hepatitis B
Existing medications suppress hepatitis B virus (HBV) DNA in blood and may delay the progression of liver disease, but they require long-term/chronic treatment with associated safety and patient compliance issues because they do not eliminate the virus from the liver.
We are using novel host-directed antivirals alone or in combination with existing drugs in a finite treatment regimen with the goal of providing functional cure of chronic hepatitis B.
Targeting:
- Suppression of HBV DNA
- Loss of hepatitis B e-antigen (HBeAg)
- Loss of hepatitis B surface antigen (HBsAg)
References:
1. Hepatitis B. World Health Organization. https://www.who.int/news-room/fact-sheets/detail/hepatitis-b. Published July 18, 2019. Accessed March 30, 2020.
2. Terrault NA, Bzowej NH, Chang KM, Hwang JP, Jonas MM, and Murad MH. 2016 AASLD Guidelines for Treatment of Chronic Hepatitis B. Hepatology. 63: 261-283.
1. Hepatitis B. World Health Organization. https://www.who.int/news-room/fact-sheets/detail/hepatitis-b. Published July 18, 2019. Accessed March 30, 2020.
2. Terrault NA, Bzowej NH, Chang KM, Hwang JP, Jonas MM, and Murad MH. 2016 AASLD Guidelines for Treatment of Chronic Hepatitis B. Hepatology. 63: 261-283.